- Candace Cameron Bure as D.J. Tanner-Fuller
- Jodie Sweetin as Stephanie Tanner
- Andrea Barber as Kimmy Gibbler
- Soni Nicole Bringas as Ramona Gibbler
- Michael Campion as Jackson Fuller
- Elias Herger as Max Fuller
- Dashiell and Fox Messitt as Tommy Fuller Jr.
- Juan Pablo Di Pace as Fernando Guerrero
- Scott Weinger as Steve Hale
- Alan Thicke as Mike
- Adam Hagenbuch as Jimmy Gibbler
- Virginia Williams as C.J.
- Gianna DiDonato as Crystal
- Alan Thicke is notable for his role as Dr. Jason Seaver on the sitcom Growing Pains, which also starred Candace Cameron Bure's brother, Kirk Cameron as Mike Seaver who Thicke's character in this episode shares a first name with. Kirk also guest starred on Full House as D.J., Stephanie, and Michelle's cousin Steve in the episode "Just One of the Guys". Alan co-starred with Candace in the holiday TV movie, Let it Snow, playing her father.
- This was also one of Alan Thicke's final television roles before his death on December 13, 2016.
| The image gallery for Mom Interference may be viewed here.